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Posted at — Sep 12, 2021

1 6.333 2020 Cleaving DNA by nanozymes

Abstract 1. DNA cleavage 2. Nanozymes 3. Hydrolytic DNA Cleavage by Nanozymes 4. Oxidative DNA Cleavage by Nanozymes 5. Light-dependent DNA cleavage 6. DNA cleavage process and mechanism 7. Comparison of nanozymes and protein-based nucleases 8. Applications of nanozyme-mediated DNA cleavage 9. Conclusions and future perspectives Acknowledgement

2 54.462 2018 Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes (II)†

摘要 1. Introduction 2. Types of nanozymes - 2.1 Peroxidase mimics - 2.1.1 Iron based. - 2.1.2 Vanadium based. - 2.1.3 Noble metal based. - 2.1.4 Carbon based. - 2.1.5 Metal–organic framework (MOF) based. - 2.1.6 Other nanomaterial based. - 2.2 Oxidase mimics - 2.2.1 Gold based. - 2.2.2 Copper based. - 2.2.3 Molybdenum based. - 2.2.4 Platinum based. - 2.3 Catalase mimics - 2.4 Superoxide dismutase (SOD) mimics - 2.4.1 Carbon based. - 2.4.2 Cerium based. - 2.4.3 Melanin based. - 2.5 Hydrolase mimics - 2.5.1 Carbon based. - 2.5.2 Monolayer functionalized AuNP based. - 2.5.3 MOF based. - 2.6 Other enzyme mimics - 2.7 Multi-enzyme-mimicking nanozymes - 2.8 Multi-functional nanozymes 3. Engineering nanozyme activity and selectivity - 3.1 Size - 3.2 Shape and morphology - 3.3 Composition - 3.4 Forming complexes or hybrids - 3.5 Surface coating and modification - 3.6 Promoters and inhibitors - 3.7 pH and temperature - 3.8 Light - 3.9 Other strategies 4. Applications - 4.1 In vitro sensing - 4.1.1 H2O2 detection. - 4.1.2 Detection of glucose and other oxidase substrates. - 4.1.3 Nucleic acid detection. - 4.1.4 Protein detection. - 4.1.5 Cell (cancer markers on cell surface) detection. - 4.1.6 Ion detection.

- 4.1.7 Others.

Conflicts of interest

    There are no conflicts to declare.

Acknowledgements

References

3 6.844 2020 Single-Atom Nanozymes for Biological Application

Astract 1. Introduction - 1.1 Enzyme-like activity of nanoparticles and discovery of nanozyme - 1.2 Rise of single-atom nanozymes - 1.3 Potential biomedical application 2. Single-atom nanozymes - 2.1 Fe single-atom nanozymes - 2.2 Pt single-atoms nanozymes - 2.3 Cu single-atoms nanozymes - 2.4 Zn single-atom nanozymes 3. Medical applications - 3.1 Cancer treatment - 3.2 Brain disease - 3.3 Wound healing Conclusion and prospective

Conflicts of interest There are no conflicts to declare.

Acknowledgements

References

4 5.8342019 Advances in chiral nanozymes: a review

Abstract Introduction Nanozymes using chemical compounds as chiral ligands Nanozymes using amino acids as chiral ligands Nanozymes using DNA as chiral ligands Perspectives Acknowledgements - Compliance with ethical standards - Conflict of interest The authors declare that they have no com- peting interests. References

5 6.223 2020 Metal–organic frameworks based nanozymes: promising materials for biochemical analysis

Abstract 1. Introduction 2. Types of MOF nanozymes - 2.1. Peroxidase - 2.2. Oxidase - 2.3. Superoxide dismutase - 2.4. Hydrolase - 2.5. Multi-enzyme assembly 3. Strategies for improving MOF nanozyme activity - 3.1. 2D MOF nanosheets - 3.2. Bimetal MOFs - 3.3. Valence state regulation - 3.4. MOF-based single-atom nanozymes 4. Multi-functionalization of MOF nanozymes - 4.1. MOF nanozymes act as natural enzyme carriers - 4.2. MOF nanozymes act as analytical signal sources 5. Biochemical sensing applications - 5.1. Detection of substrates and substrate-related molecules - 5.2. Sensing based on nanozyme activity modulation - 5.3. Detection of species impacting nanozyme catalyzed systems - 5.4. Replacing natural enzymes to generate amplified signals 6. Conclusions and perspectives

Conflicts of interest - There are no conflicts to declare.

Acknowledgements

References

6 5.26 2020 Nanozymes used for antimicrobials and their applications

Highlights Abstract 1. Introduction 2. Representative nanozymes for antibacterialactivities - 2.1 Metal or metal oxide or non-noble metal derivatives nanozymes - 2.2 Carbon-based nanozymes - 2.3 Polymer-based nanozymes 3. Antibacterial mechanism and optimization of nanozymes - 3.1 Antibacterial mechanism - 3.2 Activity optimization 4. Applications - 4.1 Nanozymes resistant bacteria - 4.2 Nanozymes scavenging biofilm 5. Conclusions and prospects

Declaration of interests

Notes The authors declare no competing financial interest.

Acknowledgements

References

7 6.032 2020 Nanozymes: created by learning from nature

摘要 Introduction Cofactors of nanozymes Metal ions ATP Other cofactors De novo synthesis of nanozymes with enzyme-like active centers Creating enzymatic microenvironment for nanozymes using amino acids Chemical synthesis of single-atom nanozymes with spatial coordination Conclusion and perspectives - Compliance and ethicsof interest.

Acknowledgements

References

8 5.89 2020 Nanozymes: A New Disease Imaging Strategy

摘要 INTRODUCTION

NANOZYMES FOR PATHOLOGICAL DISEASE DIAGNOSIS NANOZYMES FOR LIVE CELL AND ORGANELLE IMAGING NANOZYMES FOR IN VIVO IMAGING SUMMARY AND OUTLOOK AUTHOR CONTRIBUTIONS - PW, TW, ML, and XY researched the literature and wrote the review. All authors revised and polished the review.

FUNDING

SUPPLEMENTARY MATERIAL

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9 15.33 2019 When Nanozymes Meet Single-Atom Catalysis

Abstract 1. Introduction 2. Single-atom catalysts 3. Applications of SAzymes - 3.1 Sensing - 3.2 Organic pollutants degradation - 3.3 Therapy 4. Conclusion and Perspectives

Acknowledgements Keywords References

10 60.624 2019 Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications

ABSTRACT CONTENTS 1. INTRODUCTION 2. CLASSIFICATION OF NANOZYMES 3. CATALYTIC MECHANISM OF NANOZYMES - 3.1. Oxidase Family - 3.1.1. Glucose Oxidase. - 3.1.2. Sulfite Oxidase. - 3.2. Peroxidase Family - 3.2.1. Peroxidase. - 3.2.2. Glutathione Peroxidase. - 3.2.3. Haloperoxidase. - 3.3. Catalase - 3.4. Superoxide Dismutase - 3.5. Others 4. TUNING THE CATALYTIC ACTIVITIES OF NANOZYMES - 4.1. Size - 4.2. Morphology - 4.3. Surface Modification - 4.4. Composition - 4.5. Constructing Hybrid Nanomaterials - 4.6. pH and Temperature - 4.7. Ions or Molecules - 4.8. Light 5. RECENT RESEARCH PROCESS OF NANOZYMES - 5.1. Nanozymes in Sensing - 5.1.1. Detection of Ions. - 5.1.2. Detection of Molecules - 5.1.3. Detection of Nucleic Acids - 5.1.4. Detection of Proteins. - 5.1.5. Detection of Cancer Cells. - 5.2. Nanozymes in Environmental Treatment - 5.2.1. Nanozymes in Degrading Organic Pollutants in Wastewater. - 5.2.2. Nanozymes in Degrading Chemical Warfare Agents. - 5.2.3. Nanozymes in Inhibiting Biofilm Formation. - 5.3. Nanozymes in Antibacteria and Cancer Treatment - 5.3.1. Nanozymes in Antibacteria. - 5.3.2. Nanozymes in Cancer Therapy. - 5.4. Nanozymes in Antioxidation - 5.4.1. Nanozymes in Cytoprotection. - 5.4.2. Nanozymes in Alleviating Inflammation. - 5.4.3. Nanozymes in Treating Alzheimer’s Disease. - 5.4.4. Nanozymes in Treating Parkinson’s Disease.

AUTHOR INFORMATION Biographies ACKNOWLEDGMENTS ABBREVIATIONS

REFERENCES

11 7.79 2020 Light-activated nanozymes: catalytic mechanisms and applications

摘要 Introduction 1. Natural photo-related enzymes 2. Materials used and enzymatic reactions mimicked 3. Catalytic mechanism - 3.1 Electron and energy transfer - 3.2 Proof of reactive oxygen species (ROS) 4. Regulating nanozyme activity - 4.1. Doped nanozymes - 4.2. Nanozyme catalysis with mediators 5. Applications - 5.1 In vitro sensing - 5.2 Chemical synthesis - 5.3 Removal of organic pollutants - 5.4 Cleavage and repair of DNA - 5.5 Anti-bacteria activities and photodynamic therapy 6. Conclusions and future perspectives Conflicts of interest - There are no conflicts to declare.

Acknowledgements Notes and references

12 5.220 2020 Progress of Iron-Based Nanozymes for Antitumor Therapy

摘要 INTRODUCTION REACTION ROUTES UNDERLYING THE CATALYTIC ACTIVITY OF REPRESENTATIVE INs INs FOR NANOCATALYTIC CANCER THERAPY - Nanocatalysts Based on Iron Oxide Nanostructures - Other Types of Iron-Containing Nanostructures With Catalytic Activity

CRITICAL CONSIDERATIONS FOR THE IRON NANOZYME-MEDIATED BIOCATALYTIC TUMOR THERAPY - Intratumoral H2O2 Level in Cancer Cells - Optimization of the Catalytic - Microenvironment - Physicochemical Factors - Biosafety/Biocompatibility/Biodegradability - Stimulation by External Irritation

FUTURE PERSPECTIVE AND CURRENT CHALLENGES

AUTHOR CONTRIBUTIONS

FUNDING

REFERENCES